PrEP and other medications
PrEP does not interact with most other medicines.
If you are prescribed other medication, always tell your doctor (including your GP) that you are taking PrEP. You can also ask a pharmacist to check for drug interactions. This includes with over-the-counter medication.
It does not interact with alcohol or recreational drugs. It can be taken by people using hormonal contraceptives and most over-the-counter medicines. PrEP is safe for trans people taking hormones.
Tenofovir disoproxil fumarate (one of the drugs in Truvada and its generic formulations) may interact with other medicines associated with kidney problems.
These include some non-steroidal anti-inflammatory drugs (NSAIDs), especially diclofenac.
Taking both drugs together can cause kidney problems. Other NSAIDs include ibuprofen and naproxen. Avoid using these medications if you are taking PrEP, or let your doctor know if you need to take them.